on Intrasplenic Ovarian Grafts *
نویسنده
چکیده
In virgin mice of strain A, anterior hypophyseal transplants increased the incidence of mammary cancers; in castrate males bearing hypophyseal and ovarian grafts, the number of mammary can eers exceeded that noted after transplantation of ovaries alone. These findings were interpreted as owing to the release of gonadotrophins by the hy pophyseal transplants, which stimulate the output of estrogen by the animal's own or the grafted ovaries (6, 9, 10). Therefore, it seemed of interest to investigate whether or not hypophyseal trans plants might exert effects on intrasplenic ovarian grafts which are already exposed to increased ac tivity of the animal's own hypophysis.
منابع مشابه
Morphology, secretion, and transplantability of ten mouse ovarian neoplasms induced by intrasplenic ovarian grafting.
Ovaries grafted into the spleens of gonadecto mized hosts are transformed into neoplasms in rats (2,14), mice (4, 7, 9, 11, 12), and rabbits (15). Al though there is a rapidly growing literature on the production of such ovarian neoplasms, very few reports have been concerned with their transplantability. Li and Gardner (11) stated that they made successful primary subpassages of several neopla...
متن کاملInfluence of age of host and ovaries on tumorigenesis in intrasplenic and intrapancreatic ovarian grafts.
The formation of tumors in intrasplenic ovarian grafts in castrated hosts has been observed re peatedly in rats (1, 10) and mice (2, 7, 8, 9). In all the studies undertaken up to this time both young hosts and donors were used; in fact, autologous grafts have been made in most of the experiments. The theory has been proposed that ovarian tumorigcnesis occurs in the intrasplenic and intrapancrea...
متن کاملFurther studies on the pathogenesis of ovarian tumors in mice.
The formation of granulosa-cell tumors and subcutaneous tissues or testes of intact and cas luteomas in intrasplenic ovarian grafts in castrated trated mice did not readily become tumorous. rats (1) and in intrasplenic and intrapancreatic The present experiments are concerned with the ovarian grafts in castrated male and female mice influence of gonadal and gonadotrophic hormones has been repor...
متن کاملAbsence of Hepatic Inactivation of Estrogen in the Monkey *
Hepatic inactivation of estrogen is not a constant feature of the metabolism of all animals. In laboratory rodents (mouse, rat, and guinea pig) the liver effectively destroys the hormone when it is secreted by ovarian tissue transplanted to a region of portal drainage and, too, the crystalline form of the steroid is without effect when placed in a like position. On the other hand, Hooker, Drill...
متن کاملAerobic glycolysis, oxygen uptake, and enzyme activity of the electron transport system in neoplastic and non-neoplastic ovarian tissue grafted into the spleen of C57BL mice.
The lactic acid production, oxygen uptake, and activities of 5 enzymes of the electron transport system have been studied in normal ovaries, 60-day-old intrasplenic grafted ovarian tissue, and primary 12-month-old ovarian tumors developed from grafts in the spleen of C57BL mice. The 60-day-old grafted ovarian tissue, although not greatly different from normal ovaries, seems to possess quite a d...
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